Abnormality of the Buccal Mucosa which clinically resembles Leukoplakia .

Differential Diagnosis:

  • White spongy Nevus
  • Frictional Keratosis
  • Witkop’s Disease

Clinical Features:

Early stage: Filmy opalescence of the mucosa

Later stages: Grayish-white cast with a coarsely wrinkled surface

Location: Most of buccal mucosa extending onto the Lips, Seen noticeable along the occlusal line in bicuspid and molar region

Not considering the Stages the overall appearance of the Lesion is

  • Asymptomatic
  • Bilateral
  • Whitish gray
  • Semitransparent macule of the buccal mucosa

Desquamation often leads to a eroded surface

When the cheeks are stretched outward, the Leukoedema disappear which is a typical feature to demarcate Leukoedema from other similar lesions



Histologic Features:

  • Increase in thickness of the epithelium
  • Intercellular odema of spinous or malphigian layer
  • Superficial parakeratotic layer of several cells thickness
  • Broad Rete Pegs, which are irregularly elongated

The characteristic edematous cells appear extremely large and pale and are present in reticular pattern, cytoplasm appears lost and nucleus absent.

The clinical appearance of the lesion is due to the retained parakeratotic cells

Importance: Seen that it is a lesion which is most likely to develop into Oral Leukoplakia


  • As Leukodema is not a Premalignant lesion, it does not require any treatment.
  • But with the cessation of Tobacco products there can be considerable decrease in the lesion.

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