Definition: Fordyce granules or spots is a collection of sebaceous glands that occur in various locations in the oral cavity.

Synonyms: Fordyce Spots, Fordyce Disease


Inclusion of ectoderm having potentialities of skin in the oral cavity during development of maxilla & mandible- embryonic lifeFordyce Granules or Spots

Differential Diagnosis:

  • Sebaceous Hyperplasia
  • Epidermoid cyst
  • Dermoid cyst

Clinical Features:

Incidence:  80%
Age: Adults
Sex predilection :  M=F
Site or Location:

  • Buccal mucosa (opposite molar teeth)
  • Fordyce Lips
  • Retromolar region

Clinical appearance:

  • Bilaterally symmetrical
  • Small yellow spots either discreetly separated or forming plaques
  • Projecting slightly above the surface of the tissue

Histologic Features:

  • Similar to sebaceous glands of skin –but not associated with hair follicles
  • Usually superficial just beneath the overlying epithelium which often produce local elevation of the epithelium
  • Consist of few or more lobules grouped around one or more ducts which open on the surface of the mucosa

Fordyce spots or granules - Histology

Treatment of Fordyce spots or Granules:

  • Treatment is not required.
  • Inflamed glands can be treated by Clindamycin
  • But in case of any effect to physical appearance due to Fordyce spots or Granules on Lips the mode of treatment is: Laser Treatment of Fordyce spots on Lips is done
  • Neoplastic Transformation has been reported but very rare.


  • No Recurrence is seen