Verrucous Carcinoma

Verrucous Carcinoma Definition:
Verrucous Carcinoma is a diffuse papillary, non metastasizing, well differentiated malignant neoplasm of the oral epithelium.
Ackerman’s tumor.

  • Tobacco Chewing
  • Snuff dipping habits – Moistened smokeless tobacco

Clinical Features:
Age: Above 60 yrs
Sex: Males > Females

  • Most common: Gingiva, alveloar mucosa and buccal mucosa
  • Less common: Floor of the mouth

Differential Diagnosis:

  • Papillary hyperplasia
  • Verrucous leukoplakia
  • Squamous cell carcinoma
  • Chronic hyperplastic candidiasis

Clinical presentation:

  • Clinicalls it appears as a slow growing, exphytic, papillary growth having a white pebbly surface.
  • The surface fo the lesion is sometimes warty and it shows multiple rugae like folds with deep clefts in between.
  • Number: Can be Single or multiple
  • Leukoplakia may be seen
  • Mostly exophytic type but few lesions may be invasive type, invading into the underlying bone.
  • Lesions in the buccal mucosa are very extensive causing Pain and tenderness and dysphagia.
  • Lesions in the gingiva and alveolar mucosa become rapidly fixed to the periosteum and cause gradual invasion and destruction of the jaw bone.
  • regional lymph nodes are tender and
  • enlarged due to secondary infection.


  • Hyperplastic epithelium with papillary surface covered by thick layer of para keratin.
  • Rete Ridges: Enlarged bulb like acanthotic invaginating into the underlying connective tissue. project into the underlying connective tissue at the same level called as “Pushing Margin”

    Verrucous Carcinoma histology


  • “Parakeratin plugging” is seen
  • The malignant cells are well differentiated and usually show normal level of maturation
  • Abnormal mitotic activity is found in these cells.
  • Cytologic atypia is absent
  • Epithelial Pearls and Microcysts are seen.
  • Well demarcated borders.
  • Intact basement membrane and underlying connective tissues shows intense inflamatory cell infiltrate.

Surgical Excision and Laser Therapy

  1. November 19, 2014
  2. February 19, 2015
  3. June 3, 2015
  4. March 30, 2018

Leave a Reply

Your email address will not be published. Required fields are marked *

buy windows 11 pro test ediyorum