Blood Coagulation or Clotting Factors are the natural proteins which help in coagulation of blood to control bleeding, they also help to maintain the flow of blood in the body and also make sure coagulation takes place in case of any injury. In simple words Coagulation means Clotting which is seen when there is any injury to the body, the Liquid blood turns in gel form which is used to stop the bleeding from the injury site. The Clotting factors are Plasma proteins which are circulating in the Blood stream, they end up being a clot through Enzymatic cascade. Most have their own role to play in Clotting, but some Factors play a major role – Thrombin (Factor II) which is a major coagulant as it converts Fibrinogen into Fibrin which forms a major chunk of the Clot in addition to the Platelets.

Blood Coagulation Factors

13 Blood Clotting Factors in Human Body:

Factor I = Fibrinogen

Factor II = Prothrombin

Factor III = Tissue Thromboplastin

Factor IV = Calcium

Factor V = Proaccelerin, Labile factor

Factor VI – Accelerin (Does not exist as it was named initially but later on discovered not to play a part in blood coagulation)

Factor VII = Serum Prothrombin, Stable factor antihemophilic

Factor VIII = Antihemophilic factor A, Antihemophilic Globulin, Antihemophilic factor

Factor IX = Plasma Thromboplastin component, Antihemophilic factor B or Christmas factor

Factor X = Stuart Prower factor

Factor XI = Antihemophilic factor C

Factor XII = Hageman factor

Factor XIII = Fibrin stabilizing factor

Mnemonic for 13 Clotting Factors:

Mnemonic is used to help the student or Doctor make it easy to remember any specific or complicated list of content.

Foolish People Try Climbing Long Slopes After Christmas Some People Have Fallen

Factor I – Foolish – Fibrinogen

Factor II – People – Prothrombin

Factor III – Try – Tissue Thromboplastin

Factor IV – Climbing – Calcium

Factor V – Long – Labile factor (Proaccelerin)

Factor VI – Accelerin (Does not exist as it was named initially but later on discovered not to play a part in blood coagulation)

Factor VII – Slopes – Stable factor antihemophilic (Serum Prothrombin)

Factor VIII – After – Antihemophilic factor A, Antihemophilic Globulin, Antihemophilic factor

Factor IX – Christmas – Christmas factor

Factor X – Some – Stuart Prower factor

Factor XI – People – Plasma Thromboplastin Antecedent (Antihemophilic factor C)

Factor XII – Have – Hageman factor

Factor XIII – Fallen – Fibrin stabilizing factor

There is another Mnemonic which can be used for remembering the 13 Clotting Factors –

“Freshers Party Tonight Come Lets Sing And Call Seniors Please Have Fun”

Knowing about the Blood Coagulation factors in Dentistry is very important to prevent the mishaps from occurring during or after Dental procedures. There are many Hematologic disorders which are related to these factors, which makes it essential to make note of these factors and the concerning disorders.